Publications

=

2017

Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. Mena confers resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017 Jan;16(1):143-155. PMID: 27811011Featured on MIT news here.

2016

Jonas O, Oudin MJ, Kosciuk T, Whitman M, Gertler FB, Cima MJ, Flaherty KT, Langer R. Parallel In Vivo Assessment of Drug Phenotypes at Various Time Points during Systemic BRAF Inhibition Reveals Tumor Adaptation and Altered Treatment Vulnerabilities. Clin Cancer Res. 2016 Dec 15;22(24):6031-6038. PMID:27091406 

 

Weidmann MD, Surve CR, Eddy RJ, Chen X, Gertler FB, Sharma VP, Condeelis JS. MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation. Sci Rep. 2016 Nov 8;6:36142. PMID: 27824079

 

Balsamo M, Mondal C, Carmona G, McClain LM, Riquelme DN, Tadros J, Ma D, Vasile E, Condeelis JS, Lauffenburger DA, Gertler FB. The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior. Sci Rep. 2016 Oct 17;6:35298. PMID:27748415

 

Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis. Mol Biol Cell. 2016 Oct 15;27(20):3085-3094. PMID: 27559126

 

Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, Van Hemelrijck M, Cao Y, Condeelis J, Hynes RO, Gertler FB, Krause M. Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene. 2016 Sep 29;35(39):5155-69. PMID: 26996666

 

Rajadurai CV, Havrylov S, Coelho PP, Ratcliffe CD, Zaoui K, Huang BH, Monast A, Chughtai N, Sangwan V, Gertler FB, Siegel PM, Park M.5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion. J Cell Biol. 2016 Sep 12;214(6):719-34. PMID:27597754

 

Miller CL, Muthupalani S, Shen Z, Drees F, Ge Z, Feng Y, Chen X, Gong G, Nagar KK, Wang TC, Gertler FB, Fox JG. Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. PLoS One. 2016 Apr 5;11(4):e0152940. PMID: 27045955

 

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov. 2016 Apr;6(4):382-99. PMID: 26984351. Featured on MIT news here.

 

Taliaferro JM, Vidaki M, Oliveira R, Olson S, Zhan L, Saxena T, Wang ET, Graveley BR, Gertler FB, Swanson MS, Burge CB. Distal Alternative Last Exons Localize mRNAs to Neural Projections. Mol Cell. 2016 Mar 17;61(6):821-33. PMID: 26907613

 

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB. Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression. Cancer Discov. 2016 May;6(5):516-31. PMID:26811325. Featured on MIT news here.

 

Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M.Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integr Biol (Camb). 2016 Jan;8(1):73-90. PMID: 26658688

 

2015

 

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M. Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. Blood. 2015 Dec 17;126(25):2704-12. PMID:26337492

 

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood. 2015 Dec 17;126(25):2695-703. PMID: 26324702

 

Lee SY, Gertler FB, Goldberg MB.Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery. Microbiology. 2015 Nov;161(11):2149-60. PMID: 26358985

 

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell. 2015 Nov 1;26(21):3867-78. PMID: 26637385

 

Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T. Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis. Genes Dev. 2015 Sep 1;29(17):1850-62. PMID: 26341558

 

Wang J, King JE, Goldrick M, Lowe M, Gertler FB, Roberts IS. Lamellipodin Is Important for Cell-to-Cell Spread and Actin-Based Motility in Listeria monocytogenes. Infect Immun. 2015 Sep;83(9):3740-8. PMID: 26169271

 

Riquelme DN, Meyer AS, Barzik M, Keating A, Gertler FB. Selectivity in subunit composition of Ena/VASP tetramers. Biosci Rep. 2015 Jul 28;35(5). PMID: 26221026

 

Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife. 2015 Mar 11;4. PMID: 25758716

 

2014

Pignatelli J, Goswami S, Jones JG, Rohan TE, Pieri E, Chen X, Adler E, Cox D, Maleki S, Bresnick A, Gertler FB, Condeelis JS, Oktay MH. Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Sci Signal. 2014 Nov 25;7(353):ra112. PMID: 25429076

 

Barzik M, McClain LM, Gupton SL, Gertler FB. Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function. Mol Biol Cell. 2014 Sep 1;25(17):2604-19. PMID: 24989797

 

Rohan TE, Xue X, Lin HM, D'Alfonso TM, Ginter PS, Oktay MH, Robinson BD, Ginsberg M, Gertler FB, Glass AG, Sparano JA, Condeelis JS, Jones JG.Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J Natl Cancer Inst. 2014 Jun 3;106(8). PMID: 24895375

 

2013

 

Sharma VP, Eddy R, Entenberg D, Kai M, Gertler FB,  Condeelis J.T ks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells. Curr Biol. 2013 Nov 4;23(21):2079-89. PMID: 24206842

 

Belmonte SL, Ram R, Mickelsen DM, Gertler FB, Blaxall BC.Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H875-84. PMID: 23832697

 

Meyer AS, Miller MA, Gertler FB, Lauffenburger DA.The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Sci Signal. 2013 Aug 6;6(287):ra66. PMID: 23921085

 

2012

 

Agarwal S, Gertler FB, Balsamo M, Condeelis JS, Camp RL, Xue X, Lin J, Rohan TE, Rimm DL. Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast Cancer Res. 2012 Sep 12; 14(5): R124. PMCID: PMC3962029

Zervantonakis IK, Hughes-Alford SK, Charest JL, Condeelis JS, Gertler FB, Kamm RD. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34): 13515-20. PMCID: PMC3427099

Gupton SL, Riquelme D, Alford SK, Jenny Tadros, Shireen S. Rudina, Hynes RO, Lauffenburger DA, Gertler FB. Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol. 2012 Aug 20; 198(4): 657-76. PMCID: PMC3514034

Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol. 2012 Jun 11; 197(6): 721–9. PMCID: PMC3373410

 

2011

 
Roussos ET, Goswami S, Balsamo M, Wang Y, Stobezki R, Adler E, Robinson BD, Jones JG, Gertler FB, Condeelis JS, Oktay MH. Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis. 2011 Aug; 28(6): 515-27. PMCID: PMC3459587

Shapiro IM, Cheng AW, Flytzanis NC, Balsamo M, Condeelis JS, Oktay MH, Burge CB, Gertler FB. An EMT-Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype. PLoS Genet. 2011 Aug; 7(8): e1002218. PMCID: PMC3158048

Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol. 2011 Jul 24; 3(8): 989-95. PMCID: PMC3149714

Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse  model of breast cancer. J Cell Sci. 2011 Jul 1; 124(Pt 13): 2120-31. PMCID: PMC3113666

Dent EW, Gupton SL, Gertler FB. The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol. 2011 Mar 1; 3(3): PMCID: PMC3039926

Gertler F, Condeelis J. Metastasis: tumor cells becoming MENAcing. Trends Cell. Biol. 2011 Feb; 21(2): 81-90. NIHMSID: NIHMS252486 PMCID: PMC3402095

 

2010

Gupton SL, Gertler FB. Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Dev Cell. 2010 May 18; 18(5): 725-736. NIHMSID: NIHMS 199458 PMCID: PMC3383070

Roussos ET, Wang Y, Wyckoff JB, Sellers RS, Wang W, Li J, Pollard JW, Gertler FB, Condeelis JS. Mena deficiency delays tumor progression and decreases metastasis in polynoma middle-T transgenic mouse mammary tumors. Breast Cancer Res. 2010; 12(6): R101. PMCID: PMC3046446

 

2009

Bear JE, Gertler FB. Ena/VASP: towards resolving a pointed controversy at the barbed end. J Cell Sci. 2009 Jun 15; 122(12): 1947-1953. PMCID: PMC2723151

Robinson BD, Sica GL, Liu YF, Rohan TE, Gertler FB, Condeelis JS, Jones JG. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res. 2009 Apr 1; 15(7): 2433-2441. PMCID: PMC3156570

Goswami S, Philippar U, Sun D, Patsialou A, Avraham J, Wang W, Di Modugno F, Nistico, P, Gertler FB, Condeelis JS. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Met. 2009;  26(2): 153-159. PMCID: PMC3042857

 

2008

Philippar U, Roussos ET, Oser M, Yamaguch, H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell. 2008 Dec; 15(6): 813-828. PMCID: PMC2637261

Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell. 2008 Oct; 19(10): 4249-4259. PMCID: PMC2555959

 

2007

Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB. Filopodia are required for cortical neurite initiation. Nat Cell Biol. 2007 Dec; 9(12): 1347-1359. PMID: 18026093

Furman C, Sieminski AL, Kwiatkowski AV, Rubinson D, Vasile, E, Bronson RT, Fässler R, Gertler FB. Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol. 2007 Nov 19; 179(4): 761-775. PMCID: PMC2080895

Kwiatkowski AV, Rubinson DA, Dent EW, Van Veen JE, Leslie JD, Zhang J, Mebane LM, Philippar U, Pinheiro EM, Burds AA, Bronson RT, Mori S, Fässler R, Gertler FB. Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron. 2007 Nov 8; 56(3): 441-455. PMID: 17988629

Gupton SL, Gertler FB. Filopodia: the fingers that do the walking. Sci STKE. 2007 Aug 21; 2007(400): re5. Review. Erratum in: Sci STKE. 2007 Aug 28; 2007(401): er4. PMID: 17712139